Wootton Bassett, who failed to halt second-placed Carterton Town in mid-week, face local rivals Fairford Town.
Manager Pete Yeardley wants his side clear of the relegation zone but is also looking to reach mid-table if possible.
Fairford boss Mark Webb was amazed and disappointed that his outfit drew a blank against Carterton last weekend and will be looking for his side to put away some of the chances they may create this weekend.
However, they did score twice in mid-week but unfortunately for them visitors Bishops Cleeve scored four.
It was a blow for the Cinder Lane side who have the meanest defence in the Premier Division and prior to the mid-week game had only conceded 20 goals all season.
Highworth Town, who have lowered their sights to third in the table, gained a 3-1 away win over Gloucester in mid-week. Tate Hulbert, Matt Jack and a penalty from Justin Miller put the Wiltshire side in the driving seat.
Defeats for Didcot and Fairford helped John Fisher's side as they moved into third place.
Pewsey Vale face the big guns this week when they take on Carterton Town who have lost only one game in 33 outings.
Fourth from bottom in the table the Vale will need to fight every inch of the way to come out of the game with a point or two.
New College Academy notched up a 1-0 victory in mid-week over Harrow Hill and could collect another three points at home to Ross Town who are bottom of the Division One West table.
A further win could put Pete Howarth's side into the top half of the table for the first time in the season.
Purton are looking to build on last week's victory when they visit Easington Sports and a win could move them up into third spot in the table.
Shrivenham are enjoying a good run, they visit Cheltenham Saracens and it shouldn't be beyond them to come away with a victory.
Malmesbury Vics have a tough looking fixture away to Old Woodstock Town and Cirencester United face are at home against Ardley United.
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